NUR 550 Topic 1 DQ 2 Select a population health problem or issue of interest from the available studies
NUR 550 Topic 1 DQ 2 Select a population health problem or issue of interest from the available studies
NUR 550 Topic 1 DQ 2 Select a population health problem or issue of interest from the available studies
Using the GCU Library (notably the GCU Library: Nursing and Health Sciences Research Guide), find a database, journal, or other collection of resources that focuses on translational research. Select a population health problem or issue of interest from the available studies. What type of translational research is used for the study? Provide rationale as to why this is the best.NUR 550 Topic 1 DQ 2
Re: Topic 1 DQ 2
When looking through the GCU library for an interesting study containing translational research, I found this study called “Enhanced differentiation of human dopaminergic neural cell model for preclinical translational research in Parkinson’s disease.” (Harischandra et. Al, 2020). This study states that there are treatment options out there for those patients with Parkinsons, like deep brain stimulation and medications like levodopa, but these treatments are only touching the surface of the issue at hand (Harischandra et. al, 2020).NUR 550 Topic 1 DQ 2
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They state that for future (better) treatment for these patients they need to look at the dopaminergic neurons as well as the dopamine transporter (Harischandra, et. Al, 2020). They attempted to preform studies on rats but found that the cells differed in a way that would not give them accurate results (Harishchandra, et. Al, 2020). They then went on to utilize embryonic stem cells and developing these into LUHMES cells which more closely resembled the pathways they were trying to achieve (Harischandra, et. Al, 2020).
By doing their experiments on these cells they are in the T1 transition, pre patient and practice, in the lab studying the real effects on the neural pathways (Translational Research, n.d.). I’m not going to lie the study is lengthy and the process they utilized involved a ton of chemicals and days of watching these cells develop into what they needed, but at the end of 5 days their processes had drastically increased the reuptake of dopamine in the cells (Hasichandra, et. Al, 2020).NUR 550 Topic 1 DQ 2
Stem Cells are not always available for drug research so being able to develop these LUHMES cells to test on is great for the future of Parkinson’s research and for testing drugs (Harischandra et. Al, 2020).
NUR 550 Topic 1 DQ 2 Select a population health problem or issue of interest from the available studies
Harischandra, D. S., Rokad, D., Ghaisas, S., Verma, S., Robertson, A., Jin, H., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2020). Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson’s disease. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1866(4), 165533. https://doi-org.lopes.idm.oclc.org/10.1016/j.bbadis.2019.165533NUR 550 Topic 1 DQ 2
Translational Research – Defining the “T’s” | Translational Cancer Research Network. (n.d.). Www.Tcrn.Unsw.Edu. Retrieved June 18, 2021, from http://www.tcrn.unsw.edu.au/translational-research-definitions
RESPOND HERE (150 WORDS, 2 REFERENCES)
This is insightful, Sarah, the study, “Enhanced differentiation of human dopaminergic neural cell model for preclinical translational research in Parkinson’s disease.” Contains translational research expressed in different ways. The study highlighted indicates different methods or options for managing or treating Parkinson’s (Harischandra et al., 2020).NUR 550 Topic 1 DQ 2
The article further elaborates that the approaches applied only touch on the surface of the issue that has been identified. From the research study highlighted, there is the application of T1 translational research.
The approach that has been used has proved critical when it comes to the determination of the outcomes of the research process. From the study highlighted, it has been found that Parkinson’s is a disease or disorder that greatly impacts the functioning of the brain. The conditions often lead to stiffness, shaking, and difficulty with body balance, walking, as well as general coordination (Rubio et al., 2019).
NUR 550 Topic 1 DQ 2 The study highlighted that the symptoms of Parkinson’s diseases normally start and progress gradually and worsen over time. As the disease progresses, there is always difficulty in talking and walking.
References
Harischandra, D. S., Rokad, D., Ghaisas, S., Verma, S., Robertson, A., Jin, H., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2020). Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson’s disease. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1866(4), 165533. https://doi-org.lopes.idm.oclc.org/10.1016/j.bbadis.2019.165533
Rubio, I., Osuchowski, M. F., Shankar-Hari, M., Skirecki, T., Winkler, M. S., Lachmann, G., … & Bermejo-Martín, J. F. (2019). Current gaps in sepsis immunology: new opportunities for translational research. The Lancet Infectious Diseases, 19(12), e422-e436. https://www.sciencedirect.com/science/article/abs/pii/S1473309919305675
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Re: Topic 1 DQ 2 NUR 550 Topic 1 DQ 2
Incidences of stroke in the U.S. have declined in the past few years for the first time in history. However, stroke incidence among older adults has always been higher than younger adults, especially older women (Portz et al., 2018). Older adults of 80 years and above make about 17% of all stroke patients and are at high risk of mortality and prolonged hospital stays (Portz et al., 2018).NUR 550 Topic 1 DQ 2
This journal is in phase T4 type of translational research, where the information obtained in the previous stages is disseminated and implemented. This translational research aimed to investigate the impact of physical fitness and exercises for older adults with chronic stroke. A large body of literature has examined the correlation between self-management intervention such as physical fitness and exercise and chronic stroke.NUR 550 Topic 1 DQ 2
For instance, Schmid et al. (2014) observed that patients with chronic stroke showed physical improvements like body balance after enrolling in a yoga program that involved physical activities such as walking.NUR 550 Topic 1 DQ 2
Based on the previous literature, Portz et al. (2018) used the information to investigate whether physical fitness and exercise would be used as a clinical intervention for managing chronic stroke. After implementing the information, Portz et al. (2018) found that it is essential for health care professionals to incorporate self-management interventions such as physical fitness and exercise in managing chronic stroke among older adults. NUR 550 Topic 1 DQ 2
This will improve their quality of life, strength, and endurance by incorporating yoga practice. Furthermore, this kind of research will encourage more health care researchers to conduct translational research to reach phase 4 (T4), where yoga practice can be used as an evidence-based intervention for chronic stroke.
References
Portz, J. D., Waddington, E., Atler, K. E., Van Puymbroeck, M., & Schmid, A. A. (2018). Self-management and yoga for older adults with chronic stroke: A mixed-methods study of physical fitness and physical activity. Clinical Gerontologist, 41(4), 374–381. https://doi-org.lopes.idm.oclc.org/10.1080/07317115.2016.1252453
Schmid, A. A., Miller, K. K., Van Puymbroeck, M., & DeBaun-Sprague, E. (2014). Yoga leads to multiple physical improvements after stroke, a pilot study. Complementary Therapies in Medicine, 22(6), 994–1000. https://doiorg.lopes.idm.oclc.org10.1016/j.ctim.2014.09.005
RESPOND HERE (150 WORDS, 2 REFERENCES)
This is insightful Listra; stroke has been a major concern in the United States. However, over the last previous years, the incidences of stroke in the U.S. have declined. However, stroke incidence among older adults has always been higher than among younger adults, especially older women. Stroke is attributed to different factors, including overweight and unhealthy eating (Kamin et al., 2020).
The translational research and the methodology that has been applied greatly provide insight into the incidences of stroke and the approaches that can be undertaken to enhance the significant reduction in the incidences of stroke in the entire United States of America.
The type of translational research applied in the study identified is T4. The information acquired or obtained from the previous stages of research has been disseminated and implemented in the research process (Portz et al., 2018). Self-management interventions are critical in the management of cases of stroke. Some of the self-management procedures may include adherence to physical activities as well as measures that may reduce the cases of obesity.
Important information for writing discussion questions and participation
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Hello class and welcome to the class and I will be your instructor for this course. This is a -week course and requires a lot of time commitment, organization, and a high level of dedication. Please use the class syllabus to guide you through all the assignments required for the course. I have also attached the classroom policies to this announcement to know your expectations for this course. Please review this document carefully and ask me any questions if you do.
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It is required that you watch this 32-minute video as the assignments from week 3 through 5 require that you follow the instructions to the letter to succeed. Failure to complete these assignments according to instructions might lead to a zero. After watching the video, please schedule a one-on-one with me to discuss your topic for your project by the second week of class. Use this link to schedule a 15-minute session. Please, call me at the time of your appointment on my number. Please note that I will NOT call you.
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Your initial discussion post should be a minimum of 200 words and response posts should be a minimum of 150 words. Be advised that I grade based on quality and not necessarily the number of words you post. A minimum of TWO references should be used for your initial post. For your response post, you do not need references as personal experiences would count as response posts. If you however cite anything from the literature for your response post, it is required that you cite your reference. You should include a minimum of THREE references for papers in this course.
Please note that references should be no more than 5 years old except recommended as a resource for the class. Furthermore, for each discussion board question, you need ONE initial substantive response and TWO substantive responses to either your classmates or your instructor for a total of THREE responses. There are TWO discussion questions each week, hence, you need a total minimum of SIX discussion posts for each week.
I usually post a discussion question each week. You could also respond to these as it would count towards your required SIX discussion posts for the week.
I understand this is a lot of information to cover in 5 weeks, however, the Bible says in Philippians 4:13 that we can do all things through Christ that strengthens us. Even in times like this, we are encouraged by God’s word that we have that ability in us to succeed with His strength. I pray that each and every one of you receives strength for this course and life generally as we navigate through this pandemic that is shaking our world today. Relax and enjoy the course!
Hi Class,
Please read through the following information on writing a Discussion question response and participation posts.
Contact me if you have any questions.
Important information on Writing a Discussion Question
Your response needs to be a minimum of 150 words (not including your list of references)
There needs to be at least TWO references with ONE being a peer reviewed professional journal article.
Include in-text citations in your response
Do not include quotes—instead summarize and paraphrase the information
Follow APA-7th edition
Points will be deducted if the above is not followed
Participation –replies to your classmates or instructor
A minimum of 6 responses per week, on at least 3 days of the week.
Each response needs at least ONE reference with citations—best if it is a peer reviewed journal article
Each response needs to be at least 75 words in length (does not include your list of references)
Responses need to be substantive by bringing information to the discussion or further enhance the discussion. Responses of “I agree” or “great post” does not count for the word count.
Follow APA 7th edition
Points will be deducted if the above is not followed
Remember to use and follow APA-7th edition for all weekly assignments, discussion questions, and participation points.
Here are some helpful links
Student paper example
Citing Sources
The Writing Center is a great resource
I think that Dr. Dib is correct. We struggle to get our concepts tested quickly and then get that evidence to the bedside. I think that there are several other problems in the system that contribute to this problem. Douglas, et al. (2022) point out that there is a lack of innovation in the pharmaceutical industry, leading to difficulties with finding new treatments. Douglas et al. focused on rare diseases, in which the struggle is even greater, as such a small portion of the population is affected.
This leads to a lack of funding and profit, which further decreased interest and innovation (Douglas, et al., 2022). This video is from 2011, but the problem still remains in 2022, which I think highlights the rigidity of the process. Dr. Dib presses the need for the proper infrastructure to support the research teams along the path of creating to implementing innovative treatments (2011). Innovation based solely on profits is not working in this country. There are so many different steps to this highly regulated process. Dr. Dibs mention of working with the FDA is a crucial step in creating a smoother process with his organization (2011).
De Maria, T. & Dib, N. [The Genuine Article]. (2011, May 27). Translational research [Video]. YouTube. https://www.youtube.com/watch?v=IpYGTijF8e0
Douglas, C. M. W., Aith, F., Boon, W., de Neiva Borba, M., Doganova, L., Grunebaum, S., Hagendijk, R., Lynd, L., Mallard, A., Mohamed, F. A., Moors, E., Oliveira, C. C., Paterson, F., Scanga, V., Soares, J., Raberharisoa, V., & Kleinhout-Vliek, T. (2022). Social pharmaceutical innovation and alternative forms of research, development and deployment for drugs for rare diseases. Orphanet Journal of Rare Diseases, 17(1), 1–13. https://doi-org.lopes.idm.oclc.org/10.1186/s13023-022-02476-6
The video was not supposed to focus on translational research but what contributing factors there may be in why there is such a delay in implementing certain treatment and pharmacotherapeutics in the U.S. For example, lack of infrastructure, slow regulatory bodies, and cost are other contributing factors to the most significant gap in translational research in the United States.
As a result, medical schools and affiliated hospitals should recognize and promote translational and clinical research and grant a high priority to institutional findings. In turn, regulatory knowledge and support are needed to accelerate the development and implementation of new devices, medications, standards, and approaches to population wellness.
I will take a look at the video you mention as that may be a good introduction to translational research to watch. Thanks!
Reeves et al. (2017) reviewed the results of a community-based research trial to assess the efficacy of an established nutrition service designed address increased weight and obesity in children in seven communities in Australia. The Good for Kids, Good for Life (Good for Kids) program operated in seven communities found in the Hunter region in Australia.
The original study was carried out between 2006 and 2010 by what was at the time the largest public health community outreach program to address childhood obesity. Multiple sectors participated and supported the program from governmental, non-governmental, public, and private, and seven separate communities were researched.
The translational research portion of the study occurred in 2017 and was done by a special transitional health research department called Framework to Assess the Impact from Translational health research (FAIT). FAIT was created with the hope of facilitating the successful implementation of the results found in translational studies. (Reves et al., 20217)
Reference:
Reeves, P., Deeming, S., Ramanathan, S., Wiggers, J., Wolfenden, L., & Searles, A. (2017). Measurement of the translation and impact from a childhood obesity trial programme: Rationale and protocol for a research impact assessment. Health Research Policy & Systems 15, 1–7. https://doi-org.lopes.idm.oclc.org/10.1186/s12961-017-0266-9
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