NUR 550 Topic 1 DQ 1: IDENTIFY THE DIFFERENT LEVELS OF TRANSLATIONAL RESEARCH
NUR 550 Topic 1 DQ 1: IDENTIFY THE DIFFERENT LEVELS OF TRANSLATIONAL RESEARCH
Identify the different levels of translational research. Explain how translational research is different from evidence-based practice and discuss application to population health management.
Re: Topic 1 DQ 1
Translational research is form of clinical research that was first seen around 1993 (Rubio et al, 2010). So as far as research goes this is a fairly new was to look into things. There is also no clear definition of translational research, but essentially it encompasses two areas of translation one being the information obtained in pre-clinical studies, lab research and the other being the adaptation of best practices in the community with their cost effectiveness (Rubio et al, 2010). NUR 550 Topic 1 DQ 1
There are three levels of translational research, starting with T1, which involves the beginning research or development of an intervention, including the lab research, observational research and phase I and II clinical trials (Translational Research, n.d.). The second level is T2 the translation to patients, testing these interventions and their efficacy on the patient populace, including phase III clinical trials, studying how these new interventions work with disease processes and creating new guidelines with up-to-date information (Translational Research, n.d.).NUR 550 Topic 1 DQ 1
The third level is T3 disseminating and implementation of all the research into daily practice, creating the research evidence found into evidence-based practices across the profession (Translational Research, n.d.).
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From this information there isn’t a difference between evidence-based practice and translational research, it is just a way to get to evidence based practice. By following the ‘three T’s’, the final step is to put all of this research into practice, as evidence-based practice. For public health this means the most up to date care and information as the natural progression of translational practice ends with practice. NUR 550 Topic 1 DQ 1
If there is no research being done in the area however, this has a negative impact on the population, as there is not up to date EPB related to that disease process and/or its co morbidities.
NUR 550 Topic 1 DQ 1Rubio, D. M., Schoenbaum, E. E., Lee, L. S., Schteingart, D. E., Marantz, P. R., Anderson, K. E., Platt, L. D., Baez, A., & Esposito, K. (2010). Defining translational research: implications for training. Academic medicine : journal of the Association of American Medical Colleges, 85(3), 470–475. https://doi.org/10.1097/ACM.0b013e3181ccd618
Translational Research – Defining the “T’s” | Translational Cancer Research Network. (n.d.). Www.Tcrn.Unsw.Edu. Retrieved June 18, 2021, from http://www.tcrn.unsw.edu.au/translational-research-definitions
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RESPOND HERE (150 W0ORDS, 2 REFERENCES)NUR 550 Topic 1 DQ 1
This is insightful Sarah, translational research is form of clinical research that was first seen around 1993. So as far as research goes this is a fairly new was to look into things. Translational research refers to a form of study that seeks to produce more applicable, meaningful and valid outcomes that can directly impact human health. The main objective or purpose of the translational research is to translate essential science discoveries more quickly and efficiently into practices (Eske, 2020).
Translational research has been applied frequently by different researchers to enhance research processes geared towards achieving quality treatment processes and effective patient outcomes. There are three major level of translational research including T1, T2, and T3. These levels need to be incorporated into the research processes to ensure accuracy and effective outcomes in the research processes (Woolf, 2018). Level I or T1 often involves development of interventions to ensure that the entire research processes is done effectively in line with the set objectives.
ReferencesNUR 550 Topic 1 DQ 1
Woolf, S. H. (2018). The meaning of translational research and why it matters. Jama, 299(2), 211-213. https://jamanetwork.com/journals/jama/article-abstract/1149350
Eske, J. (2020, August 31). In vivo vs. in vitro: What is the difference? Medical News Today. Retrieved June 17, 2021, from https://www.medicalnewstoday.com/articles/in-vivo-vs-in-vitro
Re: Topic 1 DQ 1 NUR 550 Topic 1 DQ 1
Translational research is a new concept in my view of the world, it is a fairly new concept, as nurses we hear the term evidence-based practice (EBP) and research. Translational research is often thought of as EPB, Translational research is the research of EBP studies as well as the study and translation of EBP interventions into practice (Melnyk & Fineout-Overholt, 2019) Translational research is as stated it translates how EBP “translates” into practice, evidence-based practice is a guide to practice, translation science is the translation to implement the evidence-based research into practice. (Tilter, 2018). NUR 550 Topic 1 DQ 1
Translation research has different components to implementation of preclinical studies, phase one small clinical trials, phase 2&3 larger clinical trials, outcomes from the clinical trials, them phase 5 population outcomes research- these phases offer a “bench to bedside” continuum (Tilter, 2018).
Gaps between the availability of evidence and the placing evidence into practice has shown to partner with poor outcomes by not enabling caregivers to place the evidence into practice. (Tilter, 2018)Transitional research has shown to be beneficial in-patient outcomes and health care management by translating the evidence into practice which improves patient outcomes by the utilization of the evidence. In my field of Labor and delivery I have seen this similar process in the abundance availability of research and evidence of the increased risk of hypertension in pregnancy. NUR 550 Topic 1 DQ 1
Yet the physicians I practice with implement in very many ways through lack of translation causing early inductions and higher risk to the infants. When implementing a new technology, evidence or practice it is important to understand the research and evidence behind it as well as how best to safely implement into practice. (Sung et al., 2020) Translation research is an exciting and has multiple opportunities to advance patient outcomes, as an upcoming APRN in a magnet hospital, utilizing this process with EBP will strongly improve patient care as well as nursing practice.
References NUR 550 Topic 1 DQ 1
Melnyk, B. M., PhD, RN. APRN-CNP, FAANP, FNAP, FAAN, & Fineout-Overholt, E., PhD, RN, FNAP, FAAN. (2019). Evidence-Based Practice in Nursing& Healthcare A Guide to Best Practice (4th ed.). Wolters Kluwer.
Sung, V. W., MD MPH, Tulikangas, P., MD, Bradley, C. S., MD, MSCE, & Rideway, B., MD. (2020). Assessing and adopting New medical devices for Obstetric and Gynecologic care. ACOG, 135(4), 160–166. Retrieved May 26, 2021, from NUR 550 Topic 1 DQ 1
Tilter, M. G. (2018). Translation Research in Practice: An Introduction. Online Journal of Issues in Nursing, 23(2). Retrieved June 16, 2021, from
According to Titler (2018), translational research is a fluid process from basic research then implementing in clinical practice through public health to enhance health and its outcomes. Please complete the table (Rows 1-4) to indicate how Translation Research progresses across five phases:
T0/Basic Science Research NUR 550 Topic 1 DQ 1
1. Preclinical and animal studies
T1/Testing efficacy and safety with small group of humans
Proof of concept/ Phase 1 clinical trials
T3/ 2. Testing the efficacy and safety with larger group of humans; compare to common treatments
Phase 2 and Phase 3 clinical trials
T4/Translation to Practice
2. Clinical trials and clinical outcomes research
T5/ 4. Translation to Community
Phase 5 Population-level outcomes research
References Titler, M. G. (2018). Translation Research in Practice: An Introduction. Online Journal of Issues in Nursing, 23(2), 1. https://doi-org.lopes.idm.oclc.org/10.3912/OJIN.Vol23No02Man01
T0/ Basic Science Research: 1 Preclinical and animal studies
T1/ Testing efficacy and safety with small group of humans: Proof of concept/Phase 1 Clinical trials
T3/2 Testing the efficacy and safety with larger group of humans; compare to common treatments: Phase 2 and Phase 3 Clinical trials
T4/ Translation to Practice: 3 Clinical trials and clinical outcomes research.
T5/4 Translation to Community: Phase 5 Population- level outcome research
References
Titler, M. G. (2018). Translation Research in Practice: An Introduction. Online Journal of Issues in Nursing, 23(2), 1. https://doi-org.lopes.idm.oclc.org/10.3912/OJIN.Vol23No02Man01
Translational research appears to be a tool used to close the gap between evidence-base practice and the clinical delivery of direct nursing care. It is described as a way to improve population health and the delivery system. Translational science looks for ways to implement evidence based practice, so being something entirely different than EBP, it works hand in hand with EBP to improve patient outcomes.
Translational research digs in to make a clear understanding of what implementation strategies work, the people they work for and answers the question of why.
This body of knowledge, translation science, provides a base for guiding the selection of implementation strategies. (Titler, 2018) The are levels of translational research, T1 developing treatments and interventions, T2 testing the effectiveness of those treatments and interventions and T3 is dissemination and implementation for change.
In addition another resource describes 5 phases beginning with T0 through T5. T0 starts with basic research, preclinical. T1 is testing on a small group of humans, T2 and T3 are more trials on an even larger group of humans. T4 is the outcome research / translation to practice and lastly T5 goes out to the population or translation to the community. This type of research seems more hands on and creates positive outcomes to the patients who are in need of direct and immediate care.
reference:
Titler, M.G., (2018). Translation Research in Practice: An Introduction. OJIN: The Online Journal of Issues in Nursing 23(2). https://doi.org/10.3912/OJIN.Vol23No02Man01
Translational research – defining the “T’s”. Translational Research – Defining the “T’s” | Translational Cancer Research Network. (n.d.). Retrieved November 27, 2022, from http://www.tcrn.unsw.edu.au/translational-research-definitions#:~:text=Translational%20Pipeline&text=The%20schematic%20outlines%2Fclassifies%20the%20stages%20of%20translational%20research%20as%3A&text=T1%20%2D%20developing%20treatments%20and%20interventions.&text=T2%20%2D%20testing%20the%20efficacy%20and%20effectiveness%20of%20these%20treatments%20and%20interventions.&text=T3%20%2D%20dissemination%20and%20implementation%20research%20for%20system%2Dwide%20change.
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