Cup Plate Method | Cultivation Of Microorganism
An Adduct formed by stirring (0.01 mole) of aromatic aldehyde with the 40% of NaHSO3. O-phenylenediamine (0.01 mole) was dissolved in 50 ml of warm Ethanol 80. The NaHSO3 adduct of the aldehyde is added slowly with constant stirring in the warm solution of O-phenylenediamine stirred for 20-30 min still solid product obtained, then added 100 ml of Distilled water and filtered . Now the product was recrystallised by using Ethanol.
Step 2: Nicotinoyl Cloride
0.1 mole of Nicotinic Acid was refluxed for 6 hrs with the 20 ml of Thionyl Chloride. After this the excess of Thionyl Chloride was distilled off and separated from the product and dried it.
Step 3:
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0.01 mole of 2-phenylbenzimidazole solution in 100 ml Pyridine stirred for 8 hrs constantly with the 0.01 mole of Nicotinoyl Chloride ,then the water added 50 ml to get a solid product. The product was filtered, dried and recrystallised using Ethanol.
Scheme:
AIM AND OBJECTIVES
Molecular modification of a promising lead compound is still a major line of approach for the discovery of new drug. Molecular modification involves substituting, elimination, or adding new moieties to a parent lead compound, there by making gradual changes in the physico-chemical properties of the parent compound and thus biological activity of the compound.
It is clear from the literature review that a number of Benzimidazole derivatives are known for the, antibacterial, antifungal and ant-inflammatory activities properties.
The present studies were performed with the following objectives:
Synthesis of new series of 1,2-substituted benzimidazole derivatives.
Characterization of newly synthesized compounds by spectra methods viz.infrared spectra (IR spectra), Nuclear magnetic resonance spectra (¹H NMR spectra) and (Mass spectra).
Screening of the antibacterial and Antifungal of the newly synthesized compounds using various strains of bacteria and fungi by determining their MIC.
Screening of anti-inflammatory action of Benzimidazole derivatives.
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